Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2112718 | Cancer Letters | 2014 | 9 Pages |
Abstract
Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Cathy B. Moelans, Petra van der Groep, Laurien D.C. Hoefnagel, Marc J. van de Vijver, Pieter Wesseling, Jelle Wesseling, Elsken van der Wall, Paul J. van Diest,