Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2112897 | Cancer Letters | 2013 | 10 Pages |
Abstract
Head and neck squamous cell carcinoma (HNSCC) is the 6th commonest cancer worldwide. Relapse, thought to involve cancer stem(-like) cells (CSCs), and the development of metastases are common and survival rates remain low. Epithelial-to-mesenchymal transition (EMT) is a key event in metastasis and increasing evidence suggests a link between EMT and CSCs. MicroRNAs regulate multiple cellular processes including EMT and have been implicated in a CSC phenotype. This review aims to highlight key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.
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Authors
Chao Chen, Miriam Zimmermann, Inge Tinhofer, Andreas M. Kaufmann, Andreas E. Albers,