Nanoformulation of natural products for prevention and therapy of prostate cancer

There is a need for developing improved therapeutic options for the management of prostate cancer, able to inhibit proliferation of precancerous and malignant lesions and/or to improve the effectiveness of conventional chemopreventive and chemotherapeutic agents. In this perspective, application of nanotechnology based strategies for the delivery of natural compounds for effective management of the disease is being actively researched. Here, after highlighting the most promising natural compounds for chemoprevention and chemotherapy of prostate cancer, the state of the art nanotherapeutics and the recent proof-of-concept of “nanochemoprevention”, as well as the clinical development of promising targeted nanoprototypes for use in the prostate cancer treatment are being discussed.

► Application of nanotechnology based strategies for the delivery of natural compounds for effective management of prostate cancer is being discussed. ► Current status of nanotechnology based therapeutic options of natural products for prevention and therapy of prostate cancer are highlighted. ► The state of the art nanotherapeutics as well as the clinical development of promising targeted nanoprototypes are being discussed. ► This review also provides the base behind the up and coming applications of nanotechnology for cancer detection, imaging, treatment, and prevention.