| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2113033 | Cancer Letters | 2013 | 10 Pages |
Cancer stem cells (CSCs) have been implicated in multidrug resistance, a phenomenon responsible for the failure of cancer chemotherapy. However, the underlying mechanisms are still unclear. In our study, we established two oxaliplatin-resistant colorectal cancer cell lines displaying some CSCs characteristics. Oct4 overexpression was observed in these two lines. We performed Oct4 knock down by lentiviral vector-mediated specific shRNA. Knockdown increased apoptosis, decreased CSCs marker expression and weakened tumorigenicity in drug-resistant cell lines. In conclusion, we show that these events can be at least in part attributed to the STAT3/Survivin pathway.
► We established two oxaliplatin-resistant colorectal cancer cell lines displaying some CSCs characteristics. ► Oct4 overexpression was observed in these two lines. ► Oct4 knockdown increased apoptosis, decreased CSCs marker expression and weakened tumorigenicity in the two lines. ► These events can be at least in part attributed to the STAT3/Survivin pathway.
