Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113040 | Cancer Letters | 2013 | 9 Pages |
Abstract
Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. In this study, we found that the expression levels of HBXIP were positively associated with those of S-phase kinase-associated protein 2 (Skp2) in clinical breast cancer tissues and cell lines. Moreover, we found that HBXIP was able to stimulate the promoter of Skp2 through binding to the −640/−443 region in Skp2 promoter involving activating E2F transcription factor 1 (E2F1). Skp2 plays crucial roles in HBXIP-enhanced proliferation of breast cancer cells in vitro and in vivo. We conclude that HBXIP up-regulates Skp2 via activating E2F1 to promote proliferation of breast cancer cells.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Fuqiang Xu, Xiaona You, Fabao Liu, Xiaohong Shen, Yuanqing Yao, Lihong Ye, Xiaodong Zhang,