| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2113049 | Cancer Letters | 2013 | 9 Pages |
Primary effusion lymphoma (PEL) is a subtype of aggressive and resistant non-Hodgkin lymphoma that occurs predominantly in patients with advanced AIDS. In this study, we examined the antitumor activity of zoledronic acid (Zol)-induced Vγ9Vδ2 T cells against PEL cells in vitro and in vivo. Vγ9Vδ2 T cells recognized endogenous mevalonate metabolites and MICA/B of PEL cell lines, inducing cytotoxicity via granule exocytosis and TRAIL-mediated pathway. Vγ9Vδ2 T cells suppressed the development of PEL cells and existed in a PEL xenograft mouse model. These results show that immunotherapy with Zol-induced Vγ9Vδ2 T cells could demonstrate an efficient strategy for PEL.
► Vγ9Vδ2 T cells had the cytotoxic activity against PEL cells in vitro and in vivo. ► Mevalonate metabolites and MICA/B of PEL cells were recognized by Vγ9Vδ2 T cells. ► The cytotoxicity was mediated by granule exocytosis and TRAIL-mediated pathway. ► Vγ9Vδ2 T cells suppressed tumor growth and existed in a PEL xenograft mouse model.
