A new jasmonic acid stereoisomeric derivative induces apoptosis via reactive oxygen species in human prostate cancer cells

With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of a (−)-jasmonic acid derivative, the 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid, obtained by biotransformation, on cell growth in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. The results obtained show that the new compound was able to inhibit the growth of both prostate cancer cells. In addition, our data seem to indicate that the apoptosis evocated by this new molecule, at least in part, appears to be associated with an increase of reactive oxygen species (ROS) production.

► 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid induces apoptosis in DU-145 and LNCap cells. ► Apoptosis - 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid induced is mediated by reactive oxygen species. ► 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid could be a new therapy in prostate cancer.