Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113312 | Cancer Letters | 2012 | 8 Pages |
Abstract
Nasopharyngeal carcinoma (NPC) is endemic in southern China. In a genome-wide screen for genes inactivated by promoter hypermethylation, we identified Ras-related associated with diabetes (RRAD). Expression of RRAD was down-regulated in 83.3% (30/36) of the biopsies from NPC patients. RRAD was aberrantly methylated in 74.3% (26/35) of primary tumors, but not in normal nasopharyngeal epithelium. Ectopic RRAD expression in NPC cell lines inhibited the cell growth, colony formation, and cell migration. These results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Yingxi Mo, Kaoru Midorikawa, Zhe Zhang, Xiaoying Zhou, Ning Ma, Guangwu Huang, Yusuke Hiraku, Shinji Oikawa, Mariko Murata,