Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113316 | Cancer Letters | 2012 | 8 Pages |
Abstract
Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by S1. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death.
Keywords
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Jia-teng Zhong, Ye Xu, Hao-wei Yi, Jing Su, Hui-mei Yu, Xi-yan Xiang, Xiao-ning Li, Zhi-chao Zhang, Lian-kun Sun,