| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2113346 | Cancer Letters | 2012 | 8 Pages |
Abstract
Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of T24 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer.
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Authors
Hong Chen, Yi-Wei Lin, Ye-Qing Mao, Jian Wu, Yun-Fu Liu, Xiang-Yi Zheng, Li-Ping Xie,