| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2113408 | Cancer Letters | 2012 | 5 Pages |
Abstract
Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2 – located in mitochondria – is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated. TK1 might be helpful for screening and monitoring of human malignancies. TK1 may also serve as a prognostic factor for progression. Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given.
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Stefan Aufderklamm, Tilman Todenhöfer, Georgios Gakis, Stephan Kruck, Joerg Hennenlotter, Arnulf Stenzl, Christian Schwentner,