| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2113433 | Cancer Letters | 2012 | 7 Pages |
Abstract
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis. We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 (aldehyde dehydrogenase 1) activity. In addition, we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/β-catenin and Notch.
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Authors
Shuai Zhao, Yuichiro Kanno, Momoka Nakayama, Minami Makimura, Shiori Ohara, Yoshio Inouye,