| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2113468 | Cancer Letters | 2011 | 8 Pages |
The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and LPS decreased proliferation. This anti-proliferative effect was caspase dependent, and a decreased cell migration and matrix metalloproteinase (MMP)-9 expression were also observed. Both TLR4 and MMP-9 were highly expressed in human glioblastoma tissues. These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines.
► Fas or TLR4 (LPS receptor) pathway activation induces glioblastoma cell proliferation. ► Simultaneous cell treatment by Fas agonist antibody and LPS decreases proliferation. ► This anti-proliferative effect is caspase dependent. ► This treatment decreases cell migration and MMP-9 expression. ► Both TLR4 and MMP-9 are highly expressed in human glioblastomas.
