Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113546 | Cancer Letters | 2011 | 8 Pages |
In the present study, we sought to identify novel suppressor genes of hepatocellular carcinoma (HCC) using our newly designed triple-combination array. Using this method, the bleomycin hydrolase gene (BLMH) was detected as a candidate suppressor gene. We found that 28 of 48 (58.3%) tumor tissues showed BLMH promoter hypermethylation, and its expression level was significantly reduced in tumor tissues (P = 0.001). The present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC.
► Novel suppressor gene was identified using our designed triple-combination array. ► The bleomycin hydrolase gene was detected as a candidate suppressor gene. ► Its expression level was reduced in tumor tissues by promoter hypermethylation. ► The present study suggests that our new method can detect novel genes of interest.