Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113640 | Cancer Letters | 2011 | 7 Pages |
Abstract
The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Dandan Zheng, Yancai Wang, Dianrui Zhang, Zhaoping Liu, Cunxian Duan, Lejiao Jia, Feihu Wang, Yue Liu, Guangpu Liu, Leilei Hao, Qiang Zhang,