Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113641 | Cancer Letters | 2011 | 9 Pages |
Abstract
The purpose of this study was to assess the properties of CD4+CD25high/low/negative T cell subsets and analyze their relation with dendritic cells (DCs) in patients with hepatocellular carcinoma (HCC). In HCC patients, the prevalence of CD45RO+ cells in CD4+CD25high T cells was increased and associated with higher frequencies of plasmacytoid DCs. Larger proportions of this T cell subset were detected in the patients with larger tumor burdens. These results suggest that increased frequencies of the CD45RO+ subset in CD4+CD25high Tregs in HCC patients may establish the immunosuppressive environment cooperatively with tolerogenic plasmacytoid DCs to promote disease progression of liver cancer.
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Authors
Yoshiko Takata, Yasunari Nakamoto, Akiko Nakada, Takeshi Terashima, Fumitaka Arihara, Masaaki Kitahara, Kaheita Kakinoki, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko,