Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113643 | Cancer Letters | 2011 | 9 Pages |
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the translation of target mRNA transcripts. In this study, we demonstrated that miR-519d was downregulated in human HCC and could suppress growth of the human HCC cell line QGY-7703. Bioinformatics analysis indicated that MKi67 was a putative target of miR-519d. In an EGFP reporter system, we confirmed that MKi67 was a direct target gene of miR-519d. Furthermore, knockdown of MKi67 inhibited QGY-7703 cell growth. These findings indicate that miR-519d targets the MKi67 transcript and suppresses HCC cell growth, suggesting that miR-519d has a tumor suppressive role in human HCC pathogenesis.
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Authors
Yan-Yan Hou, Wei-Wei Cao, Lan Li, Sheng-Ping Li, Tao Liu, Hai-Ying Wan, Min Liu, Xin Li, Hua Tang,