Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113773 | Cancer Letters | 2011 | 7 Pages |
Abstract
This study used tissue samples from male B6C3F1 mice treated with ethanol in drinking water (0%, 2.5%, or 5%) for 4 or 104 weeks. We tested whether chronic alcohol drinking promotes oxidative stress in the liver and characterized the mutation profile of spontaneous and ethanol-induced tumors. We show that ethanol does not cause detectable oxidative stress in the liver at any time point and acts by promoting H-ras mutated cells.
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Cancer Research
Authors
Emmanuelle Jeannot, Igor P. Pogribny, Frederick A. Beland, Ivan Rusyn,