Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113813 | Cancer Letters | 2011 | 9 Pages |
Abstract
The present study indicated that the combination of TRAIL/Apo-2L and CA-4 exerted synergistic anti-proliferative effect against human colon carcinoma cells including SW-620 and HCT-116 in vitro. Moreover, the increased anti-tumor efficacy of TRAIL/Apo-2L combined with CA-4 was further validated on SW-620 xenograft model in nude mice. These enhanced anti-cancer activities were accompanied by caspase-mediated apoptosis. Furthermore, it was identified that NF-κB as the major determinant of TRAIL/Apo-2L resistance could be blocked in cytoplasm by TRAIL/Apo-2L plus CA-4 treatment. Taken together, these findings build the rationale for further (pre)clinical development of TRAIL/Apo-2L and CA-4 against colorectal cancer.
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Authors
Chong Zhang, Rui Wu, Hong Zhu, Yong-zhou Hu, Hai Jiang, Neng-ming Lin, Qiao-jun He, Bo Yang,