Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113832 | Cancer Letters | 2011 | 8 Pages |
Abstract
Malignant pleural mesothelioma (MPM) is a highly aggressive tumor with a poor prognosis. Thus, novel therapeutic agents need to be developed for treating it. We recently reported the isolation of the novel anti-MPM compound designated as JBIR-23 from Streptomyces sp. AK-AB27. In this study, JBIR-23 exerted its cytotoxic effect on MPM cells by promotion of tubulin polymerization and G2/M arrest, which was followed by apoptosis induction via the caspase pathway through phosphorylation of p38 mitogen-activated protein kinase and c-jun N-terminal kinase. Furthermore, in vivo analysis demonstrated that JBIR-23 prevented tumor growth in tumor-bearing nude mice without evident side effects.
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Authors
Ji-Hwan Hwang, Motoki Takagi, Hideki Murakami, Yoshitaka Sekido, Kazuo Shin-ya,