Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113851 | Cancer Letters | 2010 | 9 Pages |
Abstract
The NF-κB is best known for its role in inflammation. Here we show that constitutive NF-κB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione (GSH), which in turn confers resistance to oxidative stress. Inhibition of NF-κB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-κB activities. Concomitantly, NF-κB inhibition by pharmacological and molecular means sensitizes “NF-κB positive” cancer cells to chemically-induced oxidative stress and death. We propose that inhibition of NF-κB can reduce intracellular GSH in “NF-κB-positive” cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy.
Keywords
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Qinghang Meng, Zhimin Peng, Liang Chen, Jutong Si, Zhongyun Dong, Ying Xia,