Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2113974 | Cancer Letters | 2010 | 9 Pages |
Abstract
Previous studies in our laboratory have suggested that gankyrin expression is correlated with a malignant phenotype in colorectal cancer. Here, we investigated the possible role of gankyrin in pancreatic carcinogenesis. Gankyrin expression was significantly increased in pancreatic cancer compared to non-cancerous tissues. This expression significantly enhanced cancer cell proliferation and growth in vitro and in vivo. Suppression of gankyrin downregulated cyclin A, cyclin D1, cyclin E, CDK2, CDK4, PCNA and p-Rb but upregulated p27, Rb and p53. However, gankyrin overexpression led to opposite results. Thus, gankyrin could enhance pancreatic cancer cell proliferation by promoting cell cycle progression and p53 degradation.
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Authors
Yun Meng, Lijie He, Xuegang Guo, Shanhong Tang, Xiaodi Zhao, Rui Du, Jiang Jin, Qian Bi, Hao Li, Yongzhan Nie, Jie liu, Daiming Fan,