Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114040 | Cancer Letters | 2010 | 10 Pages |
Abstract
Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flavanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture.
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Authors
Elizabeth Brandon-Warner, James A. Sugg, Laura W. Schrum, Iain H. McKillop,