Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114086 | Cancer Letters | 2010 | 8 Pages |
Abstract
A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis.
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Authors
Ching Tung Lum, Xiong Liu, Raymond Wai-Yin Sun, Xiang-Ping Li, Ying Peng, Ming-Liang He, Hsiang Fu Kung, Chi-Ming Che, Marie C.M. Lin,