Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114171 | Cancer Letters | 2010 | 11 Pages |
Abstract
Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.
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Cancer Research
Authors
Rai-Hua Lai, Ya-Wen Hsiao, Mei-Jung Wang, Huan-Yu Lin, Chew-Wun Wu, Chin-Wen Chi, Anna Fen-Yau Li, Yuh-Shan Jou, Jeou-Yuan Chen,