| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2114263 | Cancer Letters | 2010 | 10 Pages |
Abstract
The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1–2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133− counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.
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Authors
Qunzhou Zhang, Shihong Shi, Yun Yen, Jimmy Brown, Joseph Quoc Ta, Anh D. Le,