Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114265 | Cancer Letters | 2010 | 8 Pages |
Abstract
Hepatocellular carcinoma (HCC) is one of the world’s top five causes of cancer-related deaths and treatment options are limited in this type of cancer. In the present study, we attempt to identify the novel suppressor genes of HCC using a double-combination array we designed. Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47.9%) tumor tissues showed promoter hypermethylation of LIFR gene, and the expression level was clearly reduced in tumor tissues (P < 0.0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC.
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Yukiyasu Okamura, Shuji Nomoto, Mitsuro Kanda, Qiyong Li, Yoko Nishikawa, Hiroyuki Sugimoto, Naohito Kanazumi, Shin Takeda, Akimasa Nakao,