Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114302 | Cancer Letters | 2009 | 9 Pages |
Abstract
Intracellular Ca2+ signaling plays critical roles in VEGF-mediated angiogenesis. Transient receptor potential canonical (TRPC) channel 6, a Ca2+-permeable non-selective cation channel, can be activated by VEGF. Here, we report that TRPC6 is important for VEGF-mediated angiogenesis. Inhibition of TRPC6 in human umbilical vein endothelial cells (HUVECs) by pharmacological or genetic approaches arrested HUVECs at G2/M phase and suppressed VEGF-induced HUVEC proliferation and tube formation. Furthermore, inhibition of TRPCs abolished VEGF-, but not FGF-induced angiogenesis in the chick embryo chorioallantoic membrane. These results suggest that TRPC6 plays an important role in VEGF-mediated angiogenesis.
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Authors
Ruiliang Ge, Yilin Tai, Yuanyuan Sun, Kechun Zhou, Shenglian Yang, Tianlin Cheng, Qifei Zou, Feng Shen, Yizheng Wang,