Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114303 | Cancer Letters | 2009 | 7 Pages |
Abstract
ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.
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Cancer Research
Authors
George G. Chen, Ursula P.F. Chan, Long-Chuan Bai, King Yip Fung, Art Tessier, Ann K.Y. To, Juanita L. Merchant, Paul B.S. Lai,