Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114316 | Cancer Letters | 2009 | 6 Pages |
Abstract
The plasma pharmacokinetic characteristics of the chemopreventive isothiocyanate sulforaphane were determined in six human volunteers following single and repeated intake of raw broccoli. Initially, an analytical method utilising LC–MS/MS, capable of determining low levels of sulforaphane in human plasma was developed and validated. The plasma profile of the isothiocyanate best fitted a two-compartment pharmacokinetic model. Sulforaphane was rapidly absorbed with peak plasma levels being attained within 1.5 h, and was characterised by a long terminal elimination phase. Repeated intake of broccoli had no impact on the pharmacokinetic behaviour or plasma levels of sulforaphane, and there was no evidence of accumulation.
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Authors
Natalya Hanlon, Nick Coldham, Adriana Gielbert, Maurice J. Sauer, Costas Ioannides,