Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114373 | Cancer Letters | 2009 | 10 Pages |
Abstract
Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.
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Authors
Julio E. Valdivia-Silva, Janusz Franco-Barraza, Ana Luisa Esparza Silva, Gisela Du Pont, Gloria Soldevila, Isaura Meza, Eduardo A. García-Zepeda,