Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114377 | Cancer Letters | 2009 | 10 Pages |
Abstract
The polyoma group of viruses, including SV40, is known to be oncogenic in certain species. Here we report for the first time naturally occurring, immortalized tumor cells from a patient with glioblastoma multiforme (GBM); the cells were shown to be oligodendroglia; cells had developed remarkable chromosomal changes and were positive for SV40 T antigen. Therefore, we postulated that the main cause of immortalization of these cells was the expression of SV40 T antigen gene and protein. Since the cells are naturally generated, they will provide a useful model to study the function of oligodendroglial cells and the development of GBM.
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Authors
Boe-Hyun Kim, Jun-Ho Song, Yong-Chul Jeon, Byung-Hoon Jeong, Sook-Kyung Yun, Hyoun-Chan Cho, Richard I. Carp, Yong-Sun Kim,