Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114515 | Cancer Letters | 2009 | 11 Pages |
Abstract
Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air-liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior.
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Authors
Eun Jung Kim, Zhong Min Che, Young Jin Park, Young Sun Hwang, Ki Yeol Kim, Da Woon Jung, Nam Kyung Jeon, Young Wook Choi, Eun Ju Lee, Jin Kim,