Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114535 | Cancer Letters | 2009 | 4 Pages |
Abstract
Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling.
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Authors
Leopold Ludwig, Franz Oswald, Cuong Hoang-Vu, Henning Dralle, Eberhard Hildt, Roland M. Schmid, Wolfram Karges,