Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114557 | Cancer Letters | 2009 | 9 Pages |
Abstract
The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed β-catenin-mediated transcriptional activity.
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Authors
Yu Zhang, Shuyan Huang, Wei Dong, Lin Li, Yunpeng Feng, Lina Pan, Zhenkun Han, Xiuli Wang, Guoling Ren, Dongmei Su, Baiqu Huang, Jun Lu,