Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2114727 | Cancer Letters | 2008 | 10 Pages |
Abstract
Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.
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Authors
Jens Strelau, Corina Schmeer, Heike Peterziel, Tina Sackmann, Christel Herold-Mende, Hans Steiner, Michael Weller, Klaus Unsicker,