| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2114928 | Cancer Letters | 2008 | 9 Pages |
Abstract
The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitosis and presents the rationale for these kinases as an anti-cancer target. I also review recently developed inhibitors of Aurora kinases.
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Takayuki Ikezoe,