Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115086 | Cancer Letters | 2008 | 6 Pages |
Abstract
Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211 bp (nucleotides −161 to +50 bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma.
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Authors
Lei Shi, Shu-lin Zhang, Kang Li, Yuan Hong, Qi Wang, Yue Li, Jiang Guo, Wan-hu Fan, Lei Zhang, Jun Cheng,