Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115118 | Cancer Letters | 2007 | 7 Pages |
Abstract
cSM5-1 is a mouse-human chimeric antibody which has a high specificity for hepatocellular carcinoma, melanoma and breast cancer. In this study, cSM5-1 was found to be able to inhibit cell growth and induce apoptosis in hepatocellular carcinoma cells. The antitumor activity of cSM5-1 was closely correlated with the expression level of the SM5-1 binding protein in the cancer cells. The role of caspases in cSM5-1-induced apoptosis was also investigated, indicating that cSM5-1-induced apoptosis was partially caspase-dependent and caspase-10 played a critical role. These in vitro data indicate that cSM5-1 has the potential to be a promising candidate for cancer treatment.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Jianxin Dai, Jun Jin, Bohua Li, Hao Wang, Sheng Hou, Weizhu Qian, Geng Kou, Dapeng Zhang, Jing Li, Min Tan, Jing Ma, Yajun Guo,