| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2115121 | Cancer Letters | 2007 | 11 Pages |
Abstract
Berberine is known to possess a wide variety of pharmacological activities, including pro-apoptotic activity. However, its molecular targets are not elucidated at present. NAG-1 and ATF3 are induced by several dietary compounds associated with pro-apoptotic activity. Berberine induces cell growth arrest, apoptosis, NAG-1, and ATF3 in human colorectal cancer cells. ATF3 induction by berberine is mediated in a p53-dependent manner, whereas NAG-1 induction by berberine is mediated by multiple signaling pathways. Our results suggest that berberine facilitates apoptosis and that NAG-1 and ATF3 expression plays an important role in berberine-induced apoptosis.
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Authors
Rojsanga Piyanuch, Mugdha Sukhthankar, Gritsanapan Wandee, Seung Joon Baek,