| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2115306 | Cancer Letters | 2007 | 6 Pages |
Abstract
The effects of exogenous short-chain ceramide (1) on the arrest of growth of cancer cells in vitro and induction of apoptosis have been well documented. In the present study, an analog of 1 with a disulfide linkage, N-(4â²,5â²-dithiaheptanoyl)-d-erythro-ceramide (2), was synthesized and found to be significantly more antiproliferative and cytotoxic than 1 in BT549, A549, and DU145 cancer cells. The activity was correlated with a reduction in cellular glutathione (GSH) level. Ceramide analogs with a tri- and tetra-sulfide moiety were also prepared, but they did not deplete cellular GSH levels and did not possess antiproliferative or cytotoxic properties.
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Authors
Robert Bittman, Zaiguo Li, Pranati Samadder, Gilbert Arthur,