| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2115338 | Cancer Letters | 2007 | 6 Pages |
Abstract
Aberrant promoter hypermethylation is common in oral squamous cell carcinoma (OSCC) and may be useful as a marker for cancer cells. The aim of our study was to assess whether the detection of hypermethylation of the promoter region of p16INK4a in oral cytological samples could be a marker in patients with risk of developing an OSCC. Hypermethylation was detected in 20% (29/145) of the cases analyzed. These findings provide further evidence that the inactivation of p16INK4a, due to methylation, is an early event in the carcinogenic pathway of OSCC.
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Authors
Marı´a Teresa Ruesga, Amelia Acha-Sagredo, Marı´a José RodrÃguez, José Ignacio Aguirregaviria, Juan Videgain, Carlos RodrÃguez, Marı´a de los Angeles MartÃnez de Pancorbo, José Manuel Aguirre,