Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115495 | Cancer Letters | 2006 | 9 Pages |
Abstract
RNA interference (RNAi) has been employed as an effective tool for studying gene functions. Here, we have demonstrated that different short hairpin RNAs (shRNAs) can specifically knock-down the transcription of STAT6, resulting in the inhibition of cell proliferation, G1/S phase arrest and apoptotic death in colon cancer HT-29 cells. These findings suggest that Stat6 signaling pathway plays a role in the regulation of cell proliferation and apoptosis in colon cancer cells, which promises further investigation for targeted cancer therapy.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Mingsheng Zhang, Yunfeng Zhou, Conghua Xie, Fuxiang Zhou, Yun Chen, Guang Han, Wen Jie Zhang,