Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115498 | Cancer Letters | 2006 | 6 Pages |
Abstract
Combination of a single dose of paclitaxel with three different dosages of FA resulted in significant (P<0.001) reductions in cell number from controls, paclitaxel alone, and FA treatments alone at four different time points. Combination of a single dose of carboplatin with three different dosages of FA resulted in significant (P<0.001) reductions in cell number from controls and carboplatin treatment alone at 72 and 96 h. Our data suggest that these combinations may provide an enhanced anti-tumor effect with respect to HNSCC. Since, FA can be administered orally, this regimen may introduce a paradigm change in chemotherapy for HNSCC.
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Authors
Jeffrey R. Jaglowski, Brendan C. Stack Jr.,