Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115632 | Cancer Letters | 2006 | 6 Pages |
Abstract
The impact of poly(ADP-ribose) polymerase-1 (Parpâ1)-deficiency on 4-nitroquinoline 1-oxide (4NQO)-induced carcinogenesis was studied in mice with an ICR/129Sv mixed genetic background. Parp-1+/+, Parpâ1+/â and Parp-1â/â animals given 4NQO for thirty-two weeks at 0.001% in their drinking water developed papillomas and squamous cell carcinomas of the tongue, palate and esophagus, but with no statistically significant variation with the Parpâ1 genotype. Thus Parp-1 deficiency does not elevate susceptibility to carcinogenesis induced by a carcinogen which gives rise to bulky DNA lesions. This study also indicated that the ICR/129Sv mixed genetic background is associated with high yield induction of esophageal tumors by 4NQO.
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Authors
Akemi Gunji, Akiko Uemura, Masahiro Tsutsumi, Tadashige Nozaki, Osamu Kusuoka, Ken Omura, Hiroshi Suzuki, Hitoshi Nakagama, Takashi Sugimura, Mitsuko Masutani,