| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2115686 | Cancer Letters | 2006 | 12 Pages |
Abstract
Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these motility-related proteins to inhibit cell migration. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFκB, p53, and β-catenin.
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Authors
Wei M. Liu, Xin A. Zhang,