Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115712 | Cancer Letters | 2006 | 7 Pages |
Abstract
The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. GCT patients with metastatic disease were more likely to have a variant type allele of the polymorphisms at codon 5 (age-adjusted odds ratio (aOR)=6.25; 95% CI=1.09–35.83; P=0.040) and codon 8 (aOR=4.63; 95% CI=1.35–15.93; P=0.015) than those with the localized disease. Therefore, BCL10 polymorphisms at codons 5 and 8 may play a role in the progression to advanced stage GCTs.
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Authors
Takamitsu Inoue, Takuo Ito, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Hideaki Kakinuma, Mutsuki Mishina, Eijiro Nakamura, Tetsuro Kato, Osamu Ogawa, Tomonori Habuchi,