Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115738 | Cancer Letters | 2006 | 6 Pages |
Abstract
Prognostic value of p53 protein expression in node-negative lung adenocarcinoma is still controversy. The expression of p53 protein was examined immunohistochemically in lung adenocarcinoma using monoclonal antibody BP53-12. A total 131 cases of primary lung adenocarcinoma were examined. Relationship between expression of p53 protein and clinicopathologic factors were studied. Overexpression of p53 protein was found in 19 patients (14.5%). Univariate and multivariate analysis showed that overexpression of p53 protein was an independent prognostic factor in node-negative lung adenocarcinoma. p53 alteration could be a valuable predictor for prognosis in node-negative lung adenocarcinoma.
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Authors
Hiroyuki Suzuki, Takanori Kawaguchi, Takeo Hasegawa, Atsushi Yonechi, Jun Ohsugi, Mitsunori Higuchi, Fumihiko Yamada, Yutaka Shio, Koichi Fujiu, Ryuzo Kanno, Akio Ohishi, Mitsukazu Gotoh,