Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115743 | Cancer Letters | 2006 | 8 Pages |
Abstract
One hundred and forty-five ESCC patients and 352 controls were recruited from three hospitals in Taiwan to determine the association between esophageal squamous-cell-carcinoma (ESCC) and microsomal epoxide hydrolase (mEH) genotypes at Thy113His and His139Arg. Stratified by their exposures, the His113His genotype was a significant protective factor for ESCC in areca chewers and tobacco smokers. Stratified by His113 polymorphisms, the risk of contracting ESCC for participants with His113His who chewed areca and smoked was >50% less than for those with Thy113Thy. We suggest that the mEH His113His genotype can differentiate the association between smoking, areca chewing, and ESCC.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Ying-Chu Lin, Deng-Chyang Wu, Jang-Ming Lee, Hon-Ki Hsu, Ein-Long Kao, Chien-Hui Yang, Ming-Tsang Wu,