Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115940 | Cancer Letters | 2006 | 10 Pages |
Abstract
Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERα and ERβ. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERα− ERβ+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers.
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Cancer Research
Authors
Stina Garvin, Karin Öllinger, Charlotta Dabrosin,